Liverpool had a shock defeat on its march to the Premier League title — losing 3-2 at Fulham on Sunday.
At the other end of the standings, Southampton became the first team to be relegated from England's top flight this season after a 3-1 loss to Tottenham.
Manchester United and Manchester City played out a dismal 0-0 draw at Old Trafford.
Liverpool's loss meant it missed the chance to move 14 points clear of second-place Arsenal and a step closer to a record-equaling 20th English league title.
A stunning first half from Fulham at Craven Cottage resulting in Arne Slot's Liverpool lineup lose for only the second time in the league this season.
"A very poor first half in terms of the goals we conceded. It was so unnecessary and then you're fighting a very tough battle," Liverpool captain Virgil van Dijk said.
"We tried everything in the second half but when you ship three goals in the first half it's very difficult."
Arsenal's 1-1 draw with Everton on Saturday had given Liverpool an unexpected boost in the race for the title, but despite going ahead through Alexis Mac Allister's goal in the 14th minute, the visitors were 3-1 down at halftime.
Ryan Sessegnon, Alex Iwobi and Rodrigo Muniz all found the back of the net in a thrilling 14-minute spell. Luis Diaz got Liverpool's second after the break.
Liverpool remains 11 points ahead of Arsenal and on course to win the title with seven games remaining.
