Over the course of the past decade, a team of researchers at the Institute of Life Sciences (ILS) in Bhubaneswar has made a groundbreaking discovery: the identification of a novel host protein named NCoR1 (Nuclear Receptor Co-repressor 1).

This protein exhibits immense potential in combating severe ailments such as tuberculosis and viral infections and addressing prolonged health complications associated with autoimmune diseases.

Under the guidance of Dr Sunil Kr Raghav, (Scientist F), the research group has devoted their efforts to deciphering the intricate mechanisms governed by this host protein in multifaceted diseases. Their recent study on tuberculosis has been not only published in the prestigious journal ‘PLoS Biology’ but also extensively featured in the journal ‘Autophagy’, signifying its profound impact in the scientific community.

The absence of this particular protein amplifies the bacterial burden within the host; and its expression demonstrates a strong correlation among active and recovered TB patients. The team is engaged in ongoing investigations to unravel the full spectrum of its functionality in human subjects. Prior research conducted by the group has also shed light on its pivotal role in strengthening antiviral responses. Presently, their focus extends towards exploring new dimensions linked to rheumatoid arthritis and systemic lupus erythematosus (SLE).

The preliminary results are promising; and it is expected to be extremely crucial in daily treatment regimens.