Alexis Sanchez came back to haunt Arsenal as the Chilean opened the scoring in Manchester United's 3-1 FA Cup fourth-round win to maintain Ole Gunnar Solskjaer's 100 percent record as caretaker manager.
United's winning run under the Norwegian is now eight games in all competitions and his decision to make five changes was vindicated as both Sanchez and the returning Romelu Lukaku had a huge impact.
Lukaku set up both Sanchez's opener and Jesse Lingard's second for the visitors in a two-minute spell just after the half hour mark.
Pierre-Emerick Aubameyang reduced Arsenal's arrears just before half-time and the Gunners had plenty of chances to force a replay, but were denied by Sergio Romero as the rested David de Gea was not missed.
Substitute Anthony Martial then sealed United's place in the last 16 eight minutes from time.
Handed only a second start since Solskjaer took charge, Sanchez showed why he was once in such high demand as he latched onto Lukaku's pass before rounding Cech and finishing from a narrow angle for just his second goal of the season.
Solskjaer used Lingard in the middle of a front three with Marcus Rashford and Martial on either side as threats at Tottenham.
A similar tactic with Lukaku and Sanchez this time in the wider areas worked a treat for United's second as Lukaku broke forward before his low cross was expertly dispatched by Lingard.
Arsenal were also exploiting the space in behind Lukaku at will, though, and finally made United pay two minutes before the break.
Aaron Ramsey burrowed into the penalty area and his cross was eventually turned home by Aubameyang after Alexandre Lacazette and Lucas Torreira failed to apply a telling touch.
History is repeating itself for Arsenal with Ramsey also set to leave in the summer after failing to reach an agreement over a new deal and the Welsh international again proved what a miss he will be as Romero made a brilliant save from point-blank range to deny him an equaliser early in the second period.
Arsenal's momentum in the search for an equaliser was disrupted by a lengthy delay when captain Laurent Koscielny suffered a suspected broken jaw from Lukaku's boot and had to be replaced.
Having lost Sokratis Papastathopoulos to an early ankle injury, Emery had to patch together a makeshift defence for the final half hour.
"There are two negative things today, the result and the injuries," said Emery.
By contrast, Solskjaer had the luxury of introducing Rashford and Martial for the final 18 minutes and the latter delivered the knockout blow to Arsenal by smashing home on the rebound after Cech could only parry Paul Pogba's shot.