Eoin Morgan's 10th one-day international century provided the batting foundation while seamers liam Plunkett and Chris Woakes took four wickets each as England defeated the West Indies by 45 runs in the series opener.
Extending an excellent run of form from the previous ODI series in India in January, the England captain stroked a polished 107 to pace the tourists to a competitive 296 for six.
Plunkett and Woakes then claimed four wickets each to thwart the home side's effort for an upset victory.
Half-centuries by Jason Mohammed and Jonathan Carter were not enough as the West Indies were dismissed for 251 in the 48th over, Plunkett taking the final wicket to finish with his best ODI figures of four for 40.
Woakes, who did the early damage to the Caribbean side's batting, returned with four for 47.
Accelerating from a painstaking start, Morgan timed the innings to perfection in lifting his team to a competitive total after they were put in to bat on a rain-interrupted morning at North Sound.
He faced 116 deliveries and struck 11 fours and two sixes after coming to the crease with his side in early trouble after fast bowler Shannon Gabriel removed opening batsman Jason Roy and new Test skipper Joe Root in successive overs.
Sam Billings contributed 52 at the top of the order. Ben Stokes did not disappoint either, belting 55 off 61 deliveries with three sixes and seizing the initiative from the West Indies with a 110-run fifth-wicket partnership, ended by a catch at long-on off leg-spinner Devendra Bishoo.
Morgan reached three figures in fine style, hoisting Carlos Brathwaite for a huge six over midwicket in the 48th over before the bowler had the last laugh, running out the left-hander in the final over of the innings.