Scientists have created a tiny robotic capsule that can take images inside the colon, and could replace the invasive and often painful procedure of endoscopy to detect diseases like cancer.
Known as a Sonopill, the device can be manoeuvred inside the colon to take micro-ultrasound images, which have the advantage of being better able to identify some types of cell change associated with cancer.
The device could one day replace the need for patients to undergo an endoscopic examination, where a semi-rigid scope is passed into the bowel -- an invasive procedure that can be painful.
The Sonopill is the culmination of a decade of research by an international consortium of engineers and scientists which developed a technique called intelligent magnetic manipulation.
Based on the principle that magnets can attract and repel one another, a series of magnets on a robotic arm that passes over the patient interacts with a magnet inside the capsule, gently manoeuvring it through the colon, according to a study published in the journal Science Robotics.
The magnetic forces used are harmless and can pass through human tissue, doing away with the need for a physical connection between the robotic arm and the capsule.
An artificial intelligence system (AI) ensures the smooth capsule can position itself correctly against the gut wall to get the best quality micro-ultrasound images.
The feasibility study also showed should the capsule get dislodged, the AI system can navigate it back to the required location.
"The technology has the potential to change the way doctors conduct examinations of the gastrointestinal tract," said Pietro Valdastri, from University of Leeds in the UK.
"Previous studies showed that micro-ultrasound was able to capture high-resolution images and visualise small lesions in the superficial layers of the gut, providing valuable information about the early signs of disease," said Valdastri.
"With this study, we show that intelligent magnetic manipulation is an effective technique to guide a micro-ultrasound capsule to perform targeted imaging deep inside the human body," he said.
"The platform is able to localise the position of the Sonopill at any time and adjust the external driving magnet to perform a diagnostic scan while maintaining a high quality ultrasound signal," he said.
"This discovery has the potential to enable painless diagnosis via a micro-ultrasound pill in the entire gastrointestinal tract," he added.
"With an increasing demand for endoscopies, it is more important than ever to be able to deliver a precise, targeted, and cost-effective treatment that is comfortable for patients," Sandy Cochran, a professor at the University of Glasgow in the UK.
"We hope that in the near future, the Sonopill will be available to all patients as part of regular medical check-ups, effectively catching serious diseases at an early stage and monitoring the health of everyone's digestive system," said Cochran.
The Sonopill is a small capsule -- with a diameter of 21mm and length of 39mm, which the engineers say can be scaled down. The capsule houses a micro ultrasound transducer, an LED light, camera and magnet.
A very small flexible cable is tethered to the capsule which also passes into the body via the rectum and sends ultrasound images back to a computer in the examination room.
The feasibility tests were conducted on laboratory models and in animal studies involving pigs.
Diseases of the gastrointestinal tract account for approximately 8 million deaths a year across the world, including some bowel cancers which are linked with high mortality.
