A combination of the drugs mifepristone and misoprostol can help bring closure to some women and their families suffering from miscarriage. It reduces the need for surgical intervention to complete the painful miscarriage process. Results of a new clinical trial show that while the standard drug regimen using misoprostol on its own frequently fails to complete the miscarriage, a combination of misoprostol and mifepristone works much more reliably. “Though rarely discussed openly, miscarriage is the most common complication of pregnancy, and the public health burden is both physical and psychological. I have seen my patients suffer from the insult of the treatment failure added to the injury of the initial loss,” said study lead author Courtney A. Schreiber.