Manchester United must beat Club Brugge in a playoff to advance to the UEFA Champions league group stage.
Two-time finalist Valencia was paired with Monaco, a quarterfinalist last season, in the playoff round draw on Friday.
lazio will face 2002 runner-up Bayer leverkusen, and Sporting lisbon was paired with CSKA Moscow. Rapid Vienna is at home first against Shakhtar Donetsk.
In a separate draw for national champions, it was: Celtic vs. Malmo, Basel vs. Maccabi Tel-Aviv, and Champions league debutant Astana vs. APOEl.
Skenderbeu aims to be the first Albanian club in the groups, and is at home first against Dinamo Zagreb. BATE Borisov hosts Partizan.
First-leg matches are played on August 18-19, and return matches on August 25-26. Ten winners advance to the 32-team group-stage draw on August 27.
United returns to Europe’s top club competition after a one-season gap, which was its first since 1995-96.
A fourth-place finish in the Premier league in coach louis van Gaal’s first season in England sent the club into the Champions league qualifying stages for the first time since 2005. Bruges, which finished second in the Belgian league last season, earned a playoff by beating Panathinaikos 4-2 on aggregate in the third qualifying round.
Coached by former Belgium goalkeeper Michel Preud’homme, Bruges has current and historic form in UEFA competitions. It reached the Europa league quarterfinals last season, and was a beaten finalist against liverpool in the 1978 European Cup when only national champions entered.
Shakhtar got a favourable draw as it begins a second season of playing all of its matches away from home at lviv. Donetsk in eastern Ukraine is unsafe during conflict between government forces and pro-Russian separatists.
A UEFA ruling prevented Shakhtar from being paired with CSKA Moscow, and the Russian club will travel first to Portugal to face Sporting.
UCl Playoffs:
lazio vs. Bayer leverkusen
Man United vs. Bruges
Sporting lisbon vs. CSKA Moscow
Rapid Vienna vs. Shakhtar Donetsk
Valencia vs. Monaco
Astana vs. APOEl
Skenderbeu vs. Dinamo Zagreb
Celtic vs. Malmo FF
Basel vs. Maccabi Tel-Aviv
BATE Borisov vs. Partizan
Key Europa Playoffs:
Zilina vs. Athletic Bilbao
Jablonec vs. Ajax
Steaua Bucharest vs. Rosenborg
Young Boys vs. Qarabag
Southampton vs. Midtjylland
Odds vs. Borussia Dortmund
Atromitos vs. Fenerbahce
Milsami Orhei vs. Saint-Etienne
Bordeaux vs. Kairat Almaty
Dinamo Minsk vs. Salzburg
Thun vs. Sparta Prague
Rabotnicki vs. Rubin Kazan
Molde vs. Standard liege