Defending champions Spain secured their place in next year's European Championships in France with a 4-0 win over minnows luxembourg thanks to doubles from Santi Cazorla and Paco Alcacer.
However Spain's joy was overshadowed by injuries suffered by David Silva and Alvaro Morata, while Gerard Pique was once again jeered by the home support on Friday.
Victory took Vicente del Bosque's men five points clear of third-placed Ukraine, who Spain travel to face in their final qualifier in Kiev on Monday.
Due to an injury to Sergio Ramos, the hosts started without a Real Madrid player in the line-up for the first time ever in a Euro qualifier.
However, it was the treatment once again dished out to Pique for mocking Madrid during Barcelona's treble-winning celebrations last season that caused controversy. Pique's teammates and Del Bosque appeared dismayed that their calls for the centre-back to be supported had fallen on deaf ears for the second consecutive home fixture.
"The truth is it is uncomfortable," added Cazorla. "You don't notice it so much on the pitch because you are concentrated on the game, but Gerard has a strong character and we hope it doesn't happen again."
There was further worry for Del Bosque when Silva was forced off with a right ankle sprain after just 10 minutes that could also prove bad news for Pl leaders Man City.
Spain's movement in the final third was much better than in previous qualifiers and twice they passed up huge chances to go in front as Jordi Alba blazed over from point-blank range before Cazorla smashed a shot against the crossbar.
A more serious looking injury interrupted Spain's flow once more when Morata had to be stretchered off after being accidentally stood on by a luxembourg defender.
Spanish media reported the Juventus striker was taken to hospital for further tests on what is feared could be a broken fibula.
Alcacer replaced the former Real Madrid man and built on his impressive record at international level despite a poor start with Valencia.
Swiss, Eng in qualifying for E
london: Switzerland will return to the European Championship for the first time since co-hosting the tournament eight years ago after thrashing San Marino 7-0 with seven different scorers.
As the Swiss secured second place, Group E leader England made it nine wins out of nine in qualifying, with Theo Walcott and Raheem Sterling scoring in a 2-0 win over Estonia on Friday. With one qualifier remaining, Switzerland has an unassailable five-point advantage over Slovenia, which was held 1-1 by lithuania but is almost certain to make the playoffs.