Paris Saint-Germain saw their 43-match winning run in domestic cup competitions come to an end as Thomas Tuchel's men suffered a shock 2-1 home defeat by Ligue 1 bottom club Guingamp in the French League Cup quarter-finals.
The visitors were awarded three penalties at the Parc des Princes in a dramatic second half, as PSG failed in their bid for a sixth straight League Cup title.
It was only a second defeat in all competitions this season for the capital club, after a 3-2 loss to Liverpool at Anfield in the Champions League last September. Guingamp, who have won just two league games all season, join Monaco, Strasbourg and Bordeaux in the semi-finals.
Neymar broke the deadlock in the 63rd minute after Thuram missed from the spot, but Guingamp rallied, with Thuram's successful injury-time penalty snatching victory with a shootout looming.
"We played with too much confidence, we were not hungry enough to finish the match," admitted PSG coach Thomas Tuchel. "It's very hard to lose with three penalties. I was angry with the second one, I can see the VAR 100 times, it's not a penalty."
Earlier on Wednesday, Monaco goalkeeper Loic Badiashile scored the winning penalty in a marathon shootout against Rennes.
Monaco, runners-up in the past two seasons, salvaged a 1-1 draw after normal time thanks to Rony Lopes' second-half equaliser, before Badiashile's heroics as he also saved three spot-kicks.
Thierry Henry's young team are floundering in Ligue 1, sitting second-bottom and five points from safety, but managed to keep their coach's hopes of a first trophy alive at the Stade Louis II.