Australia moved within nine wickets of completing a series clean sweep as Pakistan reached 55-1 - chasing 465 for victory - at stumps on the penultimate day of the third test.
After skipper Steve Smith declared Australia's whirlwind second innings at 241-2 midway through Friday's last session, Nathan lyon broke through four overs from stumps by removing opener Sharjeel Khan for 40.
In-form opener Azhar Ali (10 not out) and nightwatchman Yasir Shah (3 not out) will resume on Saturday when Pakistan will try to bat out the day to prevent a 3-0 series defeat. Pakistan were skittled out for 163 on the last day of the second test, failing to secure a draw.
"We want to finish this test series on a good note, so it will be better for us if we show some fight," veteran batsman Younis Khan said.
Australia's batting changed the complexion of the game. David Warner hit a blistering 23-ball half century and Smith (59) and Usman Khawaja (79 not out) also had half-centuries as Australia scored at a run-rate of 7.5 rpo in their 32 overs to set up the chance of a final day victory.
"The position we're in is pretty good, the way the guys batted today, especially Davy of course, to get those runs as quickly as possible and do some pretty unselfish batting," paceman Josh Hazelwood said. "The wicket's still pretty good, but I think there's enough there to create nine more chances."