Barcelona, Bayern Munich, Paris Saint-Germain and Porto all qualified for the Champions league last 16 on Wednesday with lionel Messi setting another personal milestone.
Messi scored both goals — one with a header for only the fourth time in the competition — as Barca beat Ajax 2-0 to equal Raul's record of 71 goals in the tournament.
“I am happy for leo because of the work he does for the team. He is the number one, the best,” said Barca midfielder Xavi Hernandez.
Bayern went through after a 2-0 victory at home to Roma, PSG saw off APOEl 1-0 while Porto beat Athletic Bilbao 2-0. Champions Real Madrid and Borussia Dortmund made sure of their last-16 places on Tuesday.
However, Chelsea missed a chance to also reach the knockout stages as they had to come from behind to snatch a 1-1 draw with minnows Maribor in Slovenia.
The 2012 winners, though, are in a far better state than English champions Manchester City whose mystifying failure to perform well in the competition continued as they had two men sent off in an embarrassing 2-1 home defeat to CSKA Moscow.
Their results rounded off a poor week for English clubs in the Champions league with liverpool losing and Arsenal drawing 3-3 with Anderlecht, the Gunners having let a 3-0 lead slip in the final half hour on Tuesday.
Ukranian side Shakhtar Donetsk also look certain to reach the last 16 after a 5-0 thrashing of Belarus champions BATE Borisov.
Porto's fellow Portuguese side Sporting lisbon are also in with a chance of reaching the next phase as they revived their campaign with a 4-2 home win over Schalke 04.
Barcelona still trail PSG by a point at the top of Group F but the Spanish side's coach luis Enrique was more relieved they had ended a run of two successive defeats. PSG coach laurent Blanc was content that his side did what was needed to secure their place in the last 16 — Edinson Cavani scoring their fastest ever goal in the competition after just 57 seconds.
Bayern's victory against an under strength Roma starting line-up — Gervinho and Francesco Totti started on the bench — came at a price as impressive defender David Alaba, who created the first goal for Franck Ribery, suffered what appeared to be a serious knee ligament injury.
City's reverse — which saw Fernandinho and Yaya Toure sent off in the second-half — left manager Manuel Pellegrini scratching his head for answers.
"It is a crisis of confidence,” said the Chilean and former Madrid manager.