Roger Federer won 37 of 40 first-serve points and stretched his Wimbledon winning streak to 29 sets in a 6-3, 7-5, 6-2 third-round victory over 64th-ranked Jan-lennard Struff of Germany.
A year ago, Federer became the first man since Bjorn Borg in 1976 to win the title without dropping a set.
Federer's best run at the All England Club is 35 consecutive sets, from 2005 to 2006.
The eight-time champion and No. 1 seed next faces 22nd-seeded Adrian Mannarino of France, who beat Daniil Medvedev 6-4, 6-3, 4-6, 5-7, 6-3.
Serena Williams's chances of winning an eighth Wimbledon and 24th Grand Slam title were boosted Friday when Madison Keys became the seventh top 10 seed to be eliminated.
Tenth seed Keys, who had made at least the quarter-finals of her last three majors, lost in the third round 7-5 5-7 6-4 to Russian qualifier Evgeniya Rodina, ranked 120th in the world.
She joins defending champion Garbine Muguruza, world number two Caroline Wozniacki, two-time champion Petra Kvitova and US Open winner Sloane Stephens in falling in the first week.
Serena, seeded 25 this year after taking time away from the tour to give birth to her daughter, faces Kristina Mladenovic of France for a place in the last 16 later Friday.
The 36-year-old American now cannot meet a top 32 player until the semi-finals after the scattering of the seeds this week.
Keys lost nine games on the trot from 5-2 up in the first set to 0-4 down in the second. She rallied to level the third-round match before Rodina sealed a maiden place in the last 16 of a major.
Keys fired 15 aces in the match but also committed 48 unforced errors.
"I have played the qualies and three matches this week which were all three sets," said 29-year-old Rodina, one of six mothers in the draw at the start of the tournament.
"She hits the ball so hard. I am a little surprised that I won, I was a little bit lucky today." later Friday, eight-time champion Roger Federer takes on German comeback specialist Jan-lennard Struff.
The world number 64 has had to fight back from two sets to love down in his first two matches to beat leonardo Mayer and 39-year-old Ivo Karlovic.
Defending champion and top seed Federer, by contrast, has made the third round without breaking sweat.
The 36-year-old Swiss has won 26 consecutive sets at the All England Club. Federer beat Struff in the second round of the Australian Open in January in straight sets.
Zverev, Anderson through
German fourth seed Alexander Zverev made the third round, seeing off Taylor Fritz of the United States 6-4 5-7 6-7 (0/7) 6-1 6-2 and faces latvian qualifier Ernests Gulbis for a spot in the last 16.
Zverev had trailed two sets to one when his tie with Fritz was halted due to darkness yesterday.
But the 21-year-old raced away with the last two sets in Friday's bright sunshine.
"Stopping last night was not a nice feeling to go to bed with," said Zverev.
"But I knew if I took my chances today, I could do well." "I am having a good season -- made the quarters at the French Open -- it's all coming together." Russia's Ekaterina Makarova defied second round victim Wozniacki's churlish prediction that she wouldn't progress further in the tournament by reaching the last 16.
Makarova, who made the quarter-finals four years ago, beat a weary-looking lucie Safarova of the Czech Republic 4-6 6-1 6-4.
She next faces Italy's Camila Giorgi who saved a match point to beat Katerina Siniakova of the Czech Republic 3-6 7-6 (8/6) 6-2.