Brazil winger Douglas Costa and midfielder Renato Augusto will miss Sunday's friendly against Croatia in liverpool because of injury.
The Brazilian football confederation says both will sit out the team's first World Cup warm-up match.
Costa has not practised with the national team since training began last week in Brazil because of a thigh injury.
Augusto's right knee has been swollen since Wednesday.
The Beijing Guoan player will likely be replaced by Manchester City midfielder Fernandinho in the starting lineup.