Roberto Martinez's Belgium was booed off the pitch against Spain. Gian Piero Ventura watched Italy's error-prone defense gift goals to France.
It was a night to forget for two coaches on their national team debuts in Thursday's friendlies.
And the future of Netherland manager Danny Blind looks bleaker after barely a year in the job after his team collapsed to Greece ahead of World Cup qualifying beginning.
But Julen lopetegui enjoyed the perfect introduction to international football coaching with Spain — at Martinez's expense — as the recently deposed European champion beat top-ranked Belgium. David Silva scored both goals as Spain outclassed Belgium, highlighting the size of the task facing former Everton manager Martinez to mold his talent-packed squad into a team capable of living up to its potential.
Elsewhere, Defender Giorgio Chiellini was to blame for Anthony Martial and Olivier Giroud scoring in the first half. On his Italy debut, 17-year-old goalkeeper Gianluigi Donnarumma also failed to protect his near post to allow layvin Kurzawa to find the net after the break. Graziano Pelle scored Italy's only goal, initially canceling out Martial's first international goal.
The Netherlands was condemned to a fifth straight home loss for the first time since 1933, highlighting the depths the team has sunk to since reaching the semifinals at the 2014 World Cup.
Georginio Wijnaldum put the Dutch in front, but the confidence ebbed out of Blind's team and Konstantinos Mitroglou headed in Greece's equaliser. Ioannis Gianniotas netted Greece's winner in the second half.
Nani seized the limelight in Cristiano Ronaldo's absence with two goals in Portugal's first match since beating France in the European Championship final in July for its first major football title to beat Gibraltar 5-0.
Meanwhile, lionel Messi marked his return from short-lived international retirement with the only goal as 10-man Argentina defeated Uruguay 1-0 to score a crucial 2018 World Cup qualifying victory.