The Drugs Controller raided 3,700 medical shops in 10 districts, including Ganjam, Gajapati, Kandhamal, Koraput, Malkangiri and Rayagada under the south zone during the 2015-16 financial year.
Sources said licences of total 752 medicine stores were cancelled during 2015-16 for flouting norms.
They include 173 stores in Ganjam district, 62 in Brahmapur, 58 in Chhatrapur and 53 in Bhanjanagar. Besides, cases were registered against four persons.
Notably, the Centre has banned sale of 344 drugs, but still some of the drugs companies are manufacturing and selling medicines.
In a recent incident, Natbar Das Medical Store in Purusottampur was raided on Tuesday on the allegation of illegally selling contraceptive without licence.
Huge quantities of tablets were seized during the crackdown conducted by Excise, Drugs, Tehsil and police officials under the supervison of Tehsildar Ipsita Priyadarshini.