lady Macbeth is a character in Shakespeare's Macbeth. She is the wife of the play's protagonist, Macbeth, a Scottish noble man. After goading him into committing regicide, she becomes Queen of Scotland, but later suffers pangs of guilt for her part in the crime. She dies off-stage in the last act as an apparent suicide. The whole story revolves around them. lady Macbeth has a powerful presence in the play, most notably in the first two acts. Following the murder of King Duncan, however, her role in the plot diminishes. She becomes an uninvolved spectator to Macbeth's plotting, and nervous host at a banquet dominated by her husband's hallucinations.