Liverpool star Sadio Mane converted a shoot-out penalty on Tuesday to take African champions Senegal to the 2022 World Cup in Qatar at the expense of Egypt.
Ghana, Morocco and Tunisia also booked their places in the finals on a frantic night of play-off action.
Senegal won the second leg of the African play-off 1-0 in Diamniadio thanks to a fourth-minute goal from Boulaye Dia and the teams finished level at 1-1 on aggregate after extra time.
As was the case in the Africa Cup of Nations final last month, Mane was entrusted with taking the crucial fifth Senegal kick and once again he made no mistake to give his side a 3-1 shoot-out victory.
Among the three Egyptians who failed to score in the shoot-out was Sane's Liverpool teammate Mohamed Salah, who uncharacteristically blazed his kick over the crossbar.
Only four of the nine penalty takers were successful with captain Kalidou Koulibaly and Saliou Ciss missing for Senegal and Salah, 'Zizo' and Mostafa Mohamed for Egypt.
As Senegal celebrated a second straight qualification for the World Cup, Egypt were left to lament another dramatic loss to Senegal this year.
There were no goals in the Cup of Nations final that went to extra time in Yaounde last month, leading to a shoot-out which Senegal won 4-2 with Mane converting the fifth penalty for his side.
The drama in Diamniadio came soon after Arsenal midfielder Thomas Partey scored the goal that took Ghana to the World Cup as they forced a 1-1 draw in Nigeria to win the play-off on away goals.
Partey struck after 10 minutes in Abuja and although another Premier League star, William Troost-Ekong, levelled from a 22nd-minute penalty, Nigeria failed to score again. The first leg ended goalless.
The Black Stars of Ghana are back in the World Cup finals after qualifying in 2006, 2010 and 2014, but missing out four years ago.
The defeat was a massive blow for favourites Nigeria, who were chasing a seventh appearance in eight attempts since debuting at the 1994 World Cup.
Azzedine Ounahi scored twice as Morocco trounced the Democratic Republic of Congo 4-1 in Casablanca to reach the finals for a sixth time.
Tarik Tissoudali and Paris Saint-Germain full-back Achraf Hakimi also netted for the Atlas Lions, who qualified 5-2 on aggregate after the first leg finished 1-1 in Kinshasa.
Tunisia secured their place in Qatar despite being held 0-0 at home by Mali in the second leg of a play-off.
Having built a 1-0 lead in Mali through a Moussa Sissako own-goal, Tunisia were unable to build on their aggregate advantage and only scraped through.
